Interprofessional practice involves healthcare practitioners from different professions working collaboratively to improve organisational and patient outcomes. Given the evidence for collaborative healthcare models 1,2, interprofessional practice is particularly important in cancer care. Multidisciplinary care is deemed best practice in the treatment planning and care for patients with cancer – it involves, ‘an integrated team approach to health care in which medical and allied health care professionals consider all relevant treatment options and collaboratively develop an individual treatment and care plan for each patient’ 3. However, interprofessional practice can be difficult to facilitate and sustain 4. This in turn can have considerable implications for patients, their carers, clinicians, and health services 5. To address this seemingly ‘wicked problem’ 6, solutions may be required that ‘lie well beyond the traditional domain of any one jurisdiction or organisational entity, and beyond business-as-usual’ 7. This article presents positive organisational scholarship in healthcare (POSH) as one such approach. Building on research in positive psychology and appreciative inquiry, among other fields 8, POSH is an emerging movement, inspiring researchers to understand human excellence in various contexts, including health services 9. Simply defined, it is ‘the study of that which is positive, flourishing and life giving in [healthcare] organisations’ 10. This is not to suggest that POSH disregards negative or even mediocre experiences – but rather, it views human experience through a positive lens and seeks to understand the factors and conditions that strengthen, if not build capacity. This paper demonstrates how a POSH approach can aid current understandings of interprofessional practice in healthcare. This is achieved through a critical appreciative inquiry into the Twitter accounts maintained by three national member-based organisations for clinicians who deliver cancer care – namely, the Cancer Nurses Society of Australia (CNSA), the Clinical Oncology Society of Australia (COSA), and Medical Oncology Group of Australia (MOGA). Over 1,300 tweets, issued during 20 months, were analysed to ascertain the positive ways these national organisations engage with different professionals and foster interprofessional practice. Findings from this study suggest POSH can offer three key benefits. First, it recognises and accommodates the messiness of interprofessional practice; second, it has the capacity to examine the phenomenon as it emerges, rather than relying on recall; and third, by advancing both theoretical and methodological debates on interprofessional practice, it may reveal opportunities to improve and sustain it within the context of healthcare.